![]() Of course, your body could be producing diindolylmethane every day depending on what your diet consists of. Further Reading Safety Concerns Regarding Diindolylmethane DIM supplementation is a natural promoter of this specific pathway of healthy estrogen metabolism. Many of the benefits traditionally ascribed to estrogen (protection from heart disease, healthy skin, bones, and brain) may actually reside with its beneficial metabolites, the 2-hydroxy estrogens. ConclusionĭIM supplementation is a nutritional approach to achieving a safer and healthier estrogen metabolism. BEFORE taking DIM please talk to your doctor about any medications you are currently on. Some of these include clozapine (Clozaril), fluvoxamine (Luvox), Imipramine (Tofranil). DIM might increase how quickly the liver breaks down some medications which can decrease the effectiveness of some medications. Some medications are changed and broken down by the liver. If you are pregnant or breastfeeding DIM should be avoided as there is currently insufficient evidence to prove its safetiness and until more is known it is best not to take DIM if you have a hormone-sensitive condition – e.g. Are there any side effects?ĭIM may cause gastrointestinal distress and headaches. Be sure to follow relevant directions on product labels and consult your pharmacist, doctor or other healthcare professional before using. Keep in mind that natural products are not always necessarily safe and dosages can be important. At this time there is not enough scientific information to determine an appropriate range of doses for DIM. The appropriate dose of DIM depends on several factors such as the user’s age, health, and several other conditions. However, direct measurements of upward, beneficial shifts in estrogen metabolism indicate you would have to eat at least two pounds per day of raw or lightly cooked cruciferous vegetables to derive the same benefit as two capsules of specially formulated DIM. Recent reports, like one from the Fred Hutchison Cancer Centre in Seattle, Washington indicate cruciferous vegetables are protective for hormone-sensitive cancers. Why not just eat more cruciferous vegetables? Taking DIM can shift the production of estrogen metabolites away from dangerous 16-hydroxy in favour of beneficial 2-hydroxy metabolites encouraging a active and healthy estrogen metabolism. What are good and bad estrogens?Įstrogen has two main metabolites, the beneficial ‘good’ 2-hydroxy and the dangerous ‘bad’ 16-hydroxy. Studies have shown that high levels of ‘bad’ estrogens (see below) can lead to mutations, abnormal growth (as in cervical dysplasia), and an increased risk of breast cancer. This is the most unhealthy form of estrogen dominance as it has the highest levels of ‘bad’ estrogens. This important form of estrogen dominance results from inheritance, diet and environmental chemicals. Estrogen is believed to contribute to benign prostatic hypertrophy (BPH).Īcquired estrogen imbalance. This corresponds to a time during which estrogen accumulates in the prostate gland. In overweight men, testosterone is increasingly converted into estrogen by aromatase and rising estrogen also competes with falling testosterone. Rising estrogen also becomes a problem for men during their 50s and 60s. Additionally, progesterone levels fall during perimenopause, resulting in a rising estrogen-to-progesterone ratio. ![]() Faltering estrogen metabolism often occurs in women during perimenopause, the years before menopause, and is characterized by higher monthly estrogen levels prior to estrogen’s dramatic fall at menopause. In women, slower hormone metabolism in midlife can mean higher-than-normal levels of estrogen and a deficiency in its healthy metabolites. There are three basic forms of this common imbalance. ![]() Middle-aged men and women experience changes in hormone production and metabolism resulting in excess estrogen action. Studies have shown that when DIM is consumed in food or in absorbable formulations it encourages healthy metabolism of estrogen, helping to resolve estrogen dominance (see below) and restore healthy hormonal balance. DIM is not an estrogen or a hormone, however, DIM and estrogen are metabolised in the body through similar metabolic pathways. These plants have been cultivated for thousands of years and were initially used for their medicinal benefits. These include cabbage, broccoli, bok choy, Brussels sprouts, cauliflower, kale, kohlrabi, mustard, rutabaga, and turnip. I3C is a phytonutrient (plant nutrient) found in cruciferous vegetables. What is DIM, and how can it help hormones?ĭIM is one of the broken down metabolites of I3C (Indole-3-Carbinol).
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